The product information provided in this site is intended only for emergency personnel and healthcare professionals in Canada only.

The products discussed herein may have different product labeling in different countries.

 

If It’s Cyanide Poisoning,
Time May Be Running Out!

 

Cyanokit contains hydroxocobalamin, an antidote indicated for the treatment of known or suspected cyanide poisoning. Cyanokit is to be administered together with appropriate decontamination and supportive measures.1

 

How CYANOKIT Works:1

 

  • When cyanide enters the body and reaches cells, it blocks the cells from utilizing oxygen
  • When tissue cells cannot utilize oxygen, they cannot function properly and may begin to die
  • Each hydroxocobalamin molecule can deactivate one cyanide ion when its hydroxo portion is replaced by the cyanide ion
  • This reaction results in the formation of non-toxic cyanocobalamin, allowing the cells to use oxygen again

 

Identifying Patients with Cyanide Poisoning

 

Cyanide poisoning may result from inhalation, ingestion, or dermal exposure to various cyanide-containing compounds, including smoke from closed space fires. Sources of cyanide poisoning include hydrogen cyanide and its salts, cyanogens, including cyanogenic plants, aliphatic nitriles, or prolonged exposure to sodium nitroprusside.1

 

The presence and extent of cyanide poisoning are often initially unknown. There is no widely available, rapid, confirmatory cyanide blood test. Treatment decisions must be made on the basis of clinical history and signs and symptoms of cyanide intoxication.1

 

If clinical suspicion of cyanide poisoning is high, Cyanokit should be administered without delay.1,2,3

 

Cyanide is an extremely toxic poison. In the absence of rapid and adequate treatment, exposure to a high dose of cyanide can result

in death within minutes.1

IMPORTANT SAFETY INFORMATION:

 

INDICATION AND CLINICAL USE: Cyanokit contains hydroxocobalamin, an antidote indicated for the treatment of known or suspected cyanide poisoning.

Cyanokit is to be administered together with appropriate decontamination and supportive measures.

 

CONTRAINDICATIONS: None. WARNINGS AND PRECAUTIONS: General: Emergency Patient Management - In addition to Cyanokit, treatment of cyanide poisoning must include immediate attention to airway patency, adequacy of oxygenation and hydration, cardiovascular support, and management of any seizure activity. Consideration should be given to decontamination measures based on the route of exposure. Cyanokit does not substitute for oxygen therapy and must not delay the set up of the above measures.

 

For important information on contraindications, warnings, precautions, adverse reactions, interactions and dosing, please consult the CYANOKIT Product Monograph.

 

®CYANOKIT is a registered trademark of SERB S.A., and is distributed in Canada by Methapharm Inc. © Copyright 2017 Methapharm Inc. - All Rights Reserved 2017. INDICATIONS AND CLINICAL USE: CYANOKIT contains hydroxocobalamin, an antidote indicated for the treatment of known or suspected cyanide poisoning. CYANOKIT is to be administered together with appropriate decontamination and supportive measures. For complete indication, contraindication, warnings and precautions see the CYANOKIT product monograph. References: 1. Eckstein M, Maniscalco PM. Focus on smoke inhalation–the most common cause of acute cyanide poisoning. Prehosp Disaster Med. 2006;21(2):s49-s55. 2. Guidotti T. Acute cyanide poisoning in prehospital care: new challenges, new tools for intervention. Prehosp Disaster Med. 2005;21(2):s40-s48. 3. CYANOKIT (single 5-g vial) [package insert]. Columbia, MD: Meridian Medical Technologies, Inc.; 2011 3. CYANOKIT (Hydroxocobalamin) Product Monograph. Date of Revision: July 5, 2016. Submission Control No: 195133.